Research Professor

203 ABNR Bldg
linchu@missouri.edu
(573) 884-6302

Dr. Lin is the lead scientist for the Center for Agroforestry’s bioremediation and natural products research programs. His primary research involves the use of plants, microbes, and engineered enzymes for bioremediation, ecological restoration, and development of the bioeconomy. His research focuses on bioremediation of organic pesticides, pharmaceuticals, petroleum contaminants, endocrine disruptors, munitions explosives, and personal care products. For natural product research, Dr. Lin’s primary foci include 1) identifying the new uses of the high-valued natural products isolated from the specialty crops and byproducts using metabolomic approach and 2) developing novel biocatalyst systems for production of biofuel and specialty chemicals, and remediation of environmental pollutants. Dr. Lin and his team have successfully transferred their inventions to the industry with spin-offs from his research including Elemental Enzymes Inc. and Tiger Enzyme Solutions. His other active research projects include air quality monitoring, chemical ecology, environmental toxicology, and biofuel research.

Research Foci

  • Bioremediation & phytoremediation
  • Ecological restoration
  • Natural products research with specialty crops

Active Grants

  • Abachi, S. (PI), Lin, C-H. (Co-PI), Hemmelgarn, H. (Co-PI), and Stubblefield, K. (Co-PI). Black Walnut Proteins as the Alternative Protein Sources in Response to Protein Supply Chain Disruption Impacted by COVID-19. Specialty Crop Block Grant H.R. 133 Stimulus Program, Missouri Department of Agriculture. 11/1/2022-10/30/2024. $49,000.
  • Bryda, E. (PI), Davis, D. (Co-PI) and Lin, C-H. (Co-PI). Effect of Black Walnut Extract Supplementation in Zucker Rats. NIH National Center for Rat Resource and Research Center. 7/1/2021-6/30/2022, $139,629.
  • Fidalgo, M. (PI) and Lin, C-H. (Co-PI) Hybrid Filtration/AOP Membrane Process for Point of use PFAS Removal From Drinking Water EPA (PI: Maria Fidalgo, CO-PI: Chung-Ho Lin) EPA P3 Program 2022-2023. $25,000.
  • Hsieh, H-Y. (PI) and Lin, C.H. (Co-PI). Development of Enzymatic Reactor for Blood Type Conversion. BioGenerator,10/1/2021-9/30/2022. $50,000.
  • Johnson, M. (PI) and Lin, C.H. (Co-PI). Coronavirus Sewershed Surveillance Project. Missouri Department of Health and Senior Services/ Center of Disease Control (CDC) Epidemiology and Laboratory Capacity for Infectious Diseases (ELC) Program. 5/30/2020-6/30/2023. $7.6 million.
  • Johnson, M. (PI) and Lin, C-H. (Co-PI). Determination of the Patient and Sewershed Factors that Modulate SARS-COV-2 RNA Detection from Wastewater. National Institute on Drug Abuse of the National Institutes of Health (NIH) 1/1/2021-12/30/2022.Total $4,000,000 (direct). Subaward to MU $2.5 million.
  • Johnson, M. and Lin, C-H. Coronavirus Sewershed Surveillance Project. The Missouri Department of Health and Senior Services (DHSS)/ Center of Disease Control (CDC) Epidemiology and Laboratory Capacity for Infectious Diseases (ELC) Program (2023-2024).
  • Krishnaswamy, K. and Lin, C-H. Seeding circular economy for upcycling food industry waste. USDA-NIFA.
  • Lin, C-H. (PI). Assessment of the Community Exposure to Fracking Chemicals.  University of Montreal. $25,000. 5/01/2022-5/30/2023.
  • Lin, C-H. (PI). Assessment of the Exposure Children to Chloroprene at Denka Plant  in LaPlace, Louisiana.  Louisiana State University. 5/01/2022-5/30/2023, $15,000.
  • Lin, C-H. (PI) and Cai, Z., (Co-PI). Explore the Economic Opportunities and Health Benefits of the Pawpaw in Missouri. Specialty Crop Block Grant Program Missouri Department of Agriculture. 11/1/2019-6/30/2022. $46,698.
  • Lin, C-H., Brockman, J., Roberts, C., and Grynyshyn, R. The Ukraine Land Reclamation Project. MU CAFNR International Collaborations Grant Program.
  • Lin, C-H. (PI). Ecophysiology, Ecosystem Services and Environmental Education of Short Rotation Woody Crops Grown for Phytotechnologies. USDA Forest Service. 9/1/2019-8/31/2024, $584,000.
  • Lin, C-H. (PI). Impact of Long-Term Cover Cropped Organic Farming Practices on the Development of Disease Suppressive Soils, USDA-NIFA/Lincoln University, 9/1/22-7/31/25, $144,391.
  • Mendoza, D. (PI), Clark, K. (Co-PI) and Lin, C-H. (Co-PI). Reducing Trade Barriers for U.S. Exports of Avocado Fruit through Multi-Pronged Strategies to Reduce Cadmium Phyto-availability and Plant Uptake. USDA Technical Assistance for Specialty Crops Program, Commodity Credit Corporation and USDA Foreign Agricultural Service. 1/1/2022 -1/1/2023, $499,000.
  • Myers, R. (PD), Conway, A. (co-PI), Udawatta, R.(co-PI), plus 16 other coPIs. An integrated approach to scaling-up climate-smart practices for crop, livestock and agroforestry production. USDA Partnership for Climate Smart Commodities. 2022-2027. Total award: $26.9 million.
  • Rogers, E. and Lin, C-H. An integrated bioremediation-phytoremediation approach for restoring mined lands. USDA-Forest Service.
  • Rogers, E. and Lin, C-H. Using specialized trees and biochar to remediate and stabilize mining waste for the Keweenaw Bay Indian Community (KBIC). USDA Forest Service.
  • Stambaugh, M.C. and Lin, C-H. Assessing fire impacts and benefits from restoration and fuel treatments to hard/yellow pine wood properties and volume production, ecosystem amenities and industry stakeholder perceptions. USDA Forest Service.
  • Sutovsky, P. (PI), McElroy, J.A. (Co-PI) and Lin, C-H. (Co-PI) Paternal Residential Exposure to Unconventional Oil and Gas Drilling (UOG). NIH-NIEHS $190,000 2022-2024. $400,000.
  • Wang, C., Rogers, E., Lin, C-H. Developing Biochar with Desired Properties for Application Demonstration of Abandoned Mine-land Reclamation at Commercial Scale. USDA Forest Service.

Selected Publications

  • Lovell, S.T., Krishnaswamy, K., Lin, CH. et al. Nuts and berries from agroforestry systems in temperate regions can form the foundation for a healthier human diet and improved outcomes from diet-related diseases. Agroforestry Systems (2023). https://doi.org/10.1007/s10457-023-00858-8
  • Adainoo, B., B. Crowell, A.L Thomas, C.-H. Lin, Z. Cai, P. Byers, M. Gold, and K. Krishnaswamy. 2022. Physical characterization of frozen fruits from eight cultivars of the North American pawpaw (Asimina triloba). Frontiers in Nutrition (Section Nutrition and Food Science Technology) 9:936192. doi: 10.3389/fnut.2022.936192.
  • Antora, S.A., K.-V. Ho, C.-H. Lin, A.L. Thomas, S.T. Lovell, and K. Krishnaswamy. 2022. Quantification of vitamins, minerals, and amino acids in black walnut (Juglans nigra). Frontiers in Nutrition: Section Nutrition and Food Science Technology 9:936109. https://doi.org/10.3389/fnut.2022.936189.
  • Bayati, M., Hsieh, H.Y., Hsu, S.Y., Li, C., Rogers, E., Belenchia, A., Zemmer, S.A., Blanc, T., LePage, C., Klutts, J., Reynold,s M., Semkiw, E., Johnson, H.Y., Foley, T., Wieberg, C.G., Wenzel, J., Lyddon, T., LePique, M., Rushford, C., Salcedo, B., Young, K., Graham, M., Suarez, R., Ford, A., Lei, Z., Sumner, L., Mooney, B.P., Wei, X., Greenlief, C.M., Johnson, M.C., Lin, C.H., 2022. Identification and quantification of bioactive compounds suppressing SARS-CoV-2 signals in wastewater-based epidemiology surveillance. Water Research 2022 Aug 1;221:118824. doi: 10.1016/j.watres.2022.118824.
  • Byers, P.L., Z. Cai, M. Gold, K. Krishnaswamy, C.-H. Lin, S. Lovell, A.L. Thomas, and M. Warmund.  2022.  Growing and Marketing Pawpaw in Missouri.  University of Missouri Center for Agroforestry, Agroforestry in Action AF1021-2022.
  • Gregory, D.A, Trujillo, M., Rushford, C., Flury, A., Kannoly, S., San, K.M., Lyfoung, D,, Wiseman, R.W., Bromert, K., Zhou, M.Y., Kesler, E., Bivens, N., Hoskins, J., Lin, C.H., O’Connor, D.H., Wieberg, C., Wenzel, J., Kantor, R.S., Dennehy, J.J., Johnson, M.C. 2022. Genetic diversity and evolutionary convergence of cryptic SARS- CoV-2 lineages detected via wastewater sequencing.  PLoS Pathogens 18(10):e1010636.  DOI: 10.1371/journal.ppat.1010636
  • Ho, K.-V., Efrat, N. Schreiber, K.L., Vo, P.H., De Canha, M.N., van Staden, A.B., Payne, B.D., Oosthuizen, C.B., Twilley, D., Lei, Z., Sumner, L.W., Brown, C.R., Lall, N., Lin, C.-H., 2022. Assessing anti-inflammatory activities and compounds in switchgrass (Panicum virgatum). Agriculture 2022, 12, 936. https://doi.org/10.3390/agriculture12070936.
  • Hooper, S.E., Amelon, S.K., Lin, C-H. 2022. Development of an LC-MS/MS Method for Non-Invasive Biomonitoring of Neonicotinoid and Systemic Herbicide Pesticide Residues in Bat Hair. Toxics. 10(2):73. https://doi.org/10.3390/toxics10020073
  • Hsu, S. Y., Bayati, M. B., Li, C., Hsieh, H. Y., Belenchia, A., Klutts, J., Zemmer, S. A., Reynolds, M., Semkiw, E., Johnson, H. Y., Foley, T., Wieberg, C. G., Wenzel, J., Johnson, M. C., & Lin, C. H., 2022. Biomarkers selection for population normalization in SARS-CoV-2 wastewater-based epidemiology. Water Research: 223, 118985, ISSN 0043-1354. https://doi.org/10.1016/j.watres.2022.118985
  • Qasim, S., Hsu, S. Y., Rossi, E., Salahshoor, Z., Lin, C. H., Parada, L. P., & Fidalgo, M. (2022). Detection of progesterone in aqueous samples by molecularly imprinted photonic polymers. Mikrochimica acta, 189(5), 174. https://doi.org/10.1007/s00604-022-05290-w
  • Robinson, C. A., Hsieh, H. Y., Hsu, S. Y., Wang, Y., Salcedo, B. T., Belenchia, A., Klutts, J., Zemmer, S., Reynolds, M., Semkiw, E., Foley, T., Wan, X., Wieberg, C. G., Wenzel, J., Lin, C. H., & Johnson, M. C. 2022. Defining biological and biophysical properties of SARS-CoV-2 genetic material in wastewater. The Science of the total environment, 807(Pt 1), 150786. https://doi.org/10.1016/j.scitotenv.2021.150786
  • Salahshoor, Z., Ho, K. V., Hsu, S. Y., Hossain, A. H., Trauth, K., Lin, C. H., & Fidalgo, M. 2022. Detection of atrazine and its metabolites in natural water samples using photonic molecularly imprinted sensors. Molecules, 27(16), 5075. https://doi.org/10.3390/molecules27165075
  • Salahshoor, Z., Ho, K.V., Hsu, S.Y., Lin, C.H., Fidalgo de Cortalezzi, M., 2022. Detection of Atrazine and its metabolites by photonic molecularly imprinted polymers in aqueous solutions, Chemical Engineering Journal Advances, Volume 12, 2022, 100368, ISSN 2666-8211, https://doi.org/10.1016/j.ceja.2022.100368.

Past publications

Bayati, M.*, D.C. Vu*, P.H. Vo*, E. Rogers*, J. Park, T.L. Ho*, A.N. Davis, Z. Gulseven, G. Carlo, F. Palermo, J.A. McElroy, S.C. Nagel, C.-H. Lin 2021. Health risk assessment of volatile organic compounds at daycare facilities. Indoor Air https://doi.org/10.1111/ina.12801

Rogers, R. E.*, R.S. Zalesny Jr. , C.-H. Lin, 2021. A systematic approach for prioritizing landfill pollutants based on toxicity: Applications and opportunities. Journal of Environmental Management 284:112013 10.1016/j.jenvman.2021.112031

Rossi, E.l, Z. Salahshoor, K.V. Ho, C.-H. Lin, M.I. Errea and M.M. Fidalgo, 2021 Detection of chlorantraniliprole residues in tomato using field-deployable MIP photonic sensors. Microchim Acta 188, 70 (2021). https://doi.org/10.1007/s00604-021-04731-2

Zalesny, R.S., M.D. Caslerb, R.A. Hallettc, C.-H. Lin, A. Pilipoviće, 2021 Chapter 9: Bioremediation and Soils. In Soils and Landscape Restoration, John A. Stanturf and Mac A. Callaham, eds., Elsevier, Pages 237-273.

Bayati, M., M. Numaan, A. Kadhem, Z. Salahshoor, S. Qasim, H. Deng, J.Lin, Z.Yan, C.-H. Lin, M. F. de Cortalezzia, 2020. Adsorption of atrazine by laser induced graphitic material: An efficient, scalable and green alternative for pollution abatement. Journal of Environmental Chemical Engineering (8): https://doi.org/10.1016/j.jece.2020.104407

Bayati, M.*, T.L. Ho*, D.C. Vu*, F. Wang,* E. Rogers*, C. Cuvellier, S. Huebotter, E.C. Inniss, R. Udawatta, S. Jose, and C.-H. Lin, 2020. Assessing the efficiency of constructed wetlands in removing PPCPs from treated wastewater and mitigating the ecotoxicological impacts. International Journal of Hygiene and Environmental Health https://doi.org/10.1016/j.ijheh.2020.113664.

Cho, S.H., K. Tóth, D. Kim, P.H. Vo*, C.-H. Lin, P, Handakumbura, A.R. Ubach, S. Evans, L. Pasa-Tolic, G. Stacey, 2020. Activation of the plant mevalonate pathway by extracellular ATP.   Nature Communications DOI: 10.21203/rs.3.rs-61470/v1

Fibrich, B.D., J. Maphutha, C.B. Oosthuizen, D. Twilley, K.V. Ho, C.-H. Lin, L.P. Vincent, T. N. Shilpa, N. P. Deepika, B. Duraiswamy, S. P. Dhanabal, S.M. Kumar, N. Lall 2020. Chapter 4: Aquatic Plants Native to America Aquatic Plants In: Aquatic Plants: Pharmaceutical and Cosmetic Applications, edited by Namrita Lall, CRC Press 366 pages. DOI: 10.1201/9780429429095-4 

Ho, K.V.*, A. Roy, S. Foote, P.H. Vo*, N. Lall, C.-H. Lin,  2020. Profiling anticancer and antioxidant activities of phenolic compounds present in black walnuts (Juglans nigra) using a high-throughput screening approach. Molecules DOI: 10.3390/molecules25194516

Ho, K.V.*,  K.L. Schreiber, D.C, Vu, S.M. Rottinghaus, D.E. Jackson, C.R. Brown, Z.Lei, L.W. Sumner, M.V. Coggeshall, C.-H. Lin 2019. Black walnut (Juglans nigra) extracts inhibit pro-inflammatory cytokine production from LPS-stimulated human pro-monocytic cell line U-937. Frontiers in Pharmacology, section Ethnopharmacology doi: 10.3389/fphar.2019.01059.

Ho, K.V.*, K.L. Schreiber, J. Park*, P.H. Vo*, Z. Lei, L.W. Sumner, C.R. Brown and C.-H. Lin, 2020. Identification and quantification of bioactive molecules inhibiting pro-inflammatory cytokine production in spent coffee grounds using metabolomics analyses. Frontiers in Pharmacology, section Ethnopharmacology doi: 10.3389/fphar.2020.00229.

Ho, T.L.*, T.T.C. Nguyen, D.C. Vu*, N.Y. Nguyen*, T.T.T. Nguyen, T.N.H. Phong, C.T. Nguyen, C.-H. Lin, Z. Lei, L.W. Sumner, and V.V. Le. 2020. Allelopathic potential of rice and identification of published allelochemicals by cloud-based metabolomics platform.  Metabolites. 2020 Jun; 10(6): 244. doi: 10.3390/metabo10060244

Hsieh, H.Y., C.-H. Lin, S.Y. Hsu*, G.C. Stewart. 2020. A Bacillus spore-based display system for bioremediation of atrazine. Applied and Environmental Microbiology DOI: 10.1128/AEM.01230-20

Johnson M. and C.-H. Lin, 2020. Standard Operating Procedure for Quantification of SARS-COV-2 in Wastewater.  The Water Research Foundation. Pages 1-15.

Lin, C.-H., Weber, E.E., Walter, W.D., Lim, T., Garrett, H.E.  2020.  Vegetative Environmental Buffers for Air Quality Benefits. Chapter 11.  In: Garrett, H.E., Jose, S. and Gold, M.A. (eds).  North American Agroforestry.  3rd Edition.  Agronomy Society of America, Madison, WI (in press)

Taleghani, A.H.*, T.T. Lim, C.-H. Lin, A.C. Ericsson and P.H. Vo*.  2020. Degradation of Veterinary antibiotics in swine manure via anaerobic digestion. Bioengineering 2020,7,123; doi:10.3390/bioengineering7040123

Vu, D.C*. J. Park*, K.V. Ho*, L.W. Sumner, Z.Lei, C. M. Greenlief, B. Mooney, M.V. Coggeshall and C.-H. Lin, 2020. Identification of health-promoting bioactive phenolics in black walnut using cloud-based metabolomics platform. Journal of Food Measurement and Characterization 14:770–777.

Alexandra N. Davis, Gustavo Carlo, Zehra Gulseven, Francisco Palermo, Chung-Ho Lin, Susan C. Nagel, Danh C. Vu, Phuc H. Vo, Thi L. Ho, and Jane A. McElroy 2019 Exposure to Environmental Toxicants and Young Children’s Cognitive and Social Development. Reviews on Environmental Health 34: 35-56.

Body, M.H. A., M.S. Zinkgraf, T.G. Whitham, C-H. Lin, R.A. Richardson, H.M. Appel, J.C. Schultz. 2019. Heritable phytohormone profiles of poplar genotypes vary in resistance to a galling aphid. Molecular Plant-Microbe Interactions. 32 (6): 654 DOI: 10.1094/MPMI-11-18-0301-R

Danh C Vu; Thi L Ho; Phuc H Vo; Mohamed Bayati; Alexandra N Davis; Zehra Gulseven; Gustavo Carlo; Francisco Palermo; Jane McElroy; Susan Nagel; Chung-Ho Lin. 2019 Assessment of Indoor Volatile Organic Compounds in Head Start Child Care Facilities. Atmospheric Environment.

Jeanne Dollinger, Chung-Ho Lin, Ranjith Udawatta, Valerie Pot, Pierre Benoit, Shibu Jose 2019 Influence of agroforestry plant species on the infiltration of S-Metolachlor in buffer soils. Journal of Contaminant Hydrology 225: https://doi.org/10.1016/j.jconhyd.2019.103498

Lyndy Joy McGaw, Ajay Kumar Srivastava, Chung-Ho Lin, Vanessa Steenkamp 2019 Book Review: Medicinal Plants for Holistic Healing. Frontiers in Pharmacology, section Ethnopharmacology (in press)

McGaw, L.J., A.K. Srivastava, C.-H. Lin, V. Steenkamp, 2019. Book Review: Medicinal Plants for Holistic Healing. Frontiers in Pharmacology, section Ethnopharmacology https://doi.org/10.3389/fphar.2019.01053

Melanie J. A. Body, William C. Neer, Caitlin Vore, Chung-Ho Lin, Danh C. Vu, Jack C. Schultz, Reginald B. Cocroft and Heidi M. Appel. 2019 Caterpillar Chewing Vibrations Cause Changes in Plant Hormones and Volatile Emissions in Arabidopsis thaliana. Front. Plant Sci., 26 June 2019 | https://doi.org/10.3389/fpls.2019.00810

Vu, D.C., Lei, Z.,Coggeshall, M.V., Sumner, L.W.and Lin, C.-.H. 2019 Identification and Quantification of Phytosterols in Black Walnut Kernels. Journal of Food Composition and Analysis. Food Composition and Analysis 75, 61-69



Patent Applications

  • George Stewart, Brain Thompson, and Chung-Ho Lin 2019. Bacillus Based Delivery System and Methods of Use 2019 U.S. Patent No. 10,081,790
  • A contaminant reducing amide functionalized ordered mesoporous carbon conjugate (Granted 2013, US 13/448,065)
  • Development of nanocarbon-based biocatalyst for remediation of environmental pollutants (US2013/0280781 A1 Second Divisional Patent)
  • Development of spore-based biocatalyst for remediation of pollutants and biofuel production (Granted, U.S. Application Serial Nos. 13/089,015, USA 14/849,295. 2015; Spin-off: Elemental Enzymes Inc.)
  • Multi-Enzyme Platform Production of Specialty Chemicals, Biofuels, and Blood Type Conversion. 2017 (Provisional patient granted; Spin-off: Tiger Energy Solutions)

Invention Disclosures

  • Use of tricyclic diternpenoids from Eastern Redcedar (Juniperus virginiana) for preventing and ameliorating the development of melanin and hyperpigmentation
  • Purification of anti-microbial, anti-fungal and anti-inflammatory diterpenoids from Eastern redcedar (Juniperus virginiana).
  • Purification of the bioactive saponin Esculentoside D. from Phytolacca latbenia.
  • Use of N-trans-cinnamoyltyramine from rice (Oryza sativa) for weed control
  • Chemical synthesis of N-trans-cinnamoyltyramine and it analogs for agricultural and medical applications.
  • A novel computer implemented 3D printing method for platforms for enzyme immobilization. 2017 (Invention Disclosure Submitted)
  • Spent coffee grounds for cosmetic application. 2017 (Invention Disclosure Submitted)

Explore more resources from Dr. Lin and the Center for Agroforestry team.

READ

The Mizzou College of Ag, Food, and Natural Resources features Dr. Lin’s project to help Ukrainian farmers restore farmland damaged in the Russian war.

WATCH

Dr. Lin explains his research on how eastern red cedar trees, often disregarded for their low timber value, can create high-value medicinal products.

LISTEN

Dr. Lin presents a lecture on identifying value-added, health-promoting compounds from waste plant materials at the 2017 Agroforestry Symposium.

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